2 CBJ:
I have exactly the same problem. I also offer my help to see the problem gets solved, as it is now stopping me from advanced further. I just bought the second system just to play X3, and I can ghost one OS to another pretty quickly (ha-ha 30 seconds to be exact

. So if there is anything I can do to help to solve this and other bugs in the game that I come across don't hesitate to contact me. It looks like my kind of game, and I like to see it get better.
Can you also post a guideline for a bug report in your place, or a template, or whatever you call it, so we don't feel like complete idiots writing essays on the problems' we're having.
THE PROBLEM:
It started as I couldn't fire a missile - every missile lead to desktop (on the older version of drivers I think 78.01 - 05), on the newer 81.* just death - only reset will bring the system back.
Finally I nailed the problem to the second little monitor (on the right) following the missile. Switching it off I was able to play for another few days (3 - 4 hours a day) now even that does not help.
Now the game crashes every time I select something as a target with the HUD on. With the HUD off it's ok, but you can't do much without it... Looks like the second litte monitor is to blame.
What's chnaged in that time:
I got Automated Trader - prolly additinal processor load,
Got a few factories loaded in Mamonth, but not deployed yet - shouldn't make any diff.
Expored sectors in the Spring Of Hope area - large but empty sectors, though that was there the problem started to escalate.
Ah, yeah, I also switched from Mako to the Free Split Mamba found in sector (you know which

, probs actually started since mamba.
Now every time I try to select the target I'm either at desktop or crashed dependent on drivers. The prob is I can't switch off the left little monitor, unless I have something selected, but as soon as I select something I'm crashed. How to find the option of switching off the left little monitor?
Tech stuff - the system is stable allright - I was able to play for about 12 hours a day for two days without the crashes - so as far as game concern the hardware is sound. Though is rather new
MB: ASUS 955X P5WD2
Intel P4 3.2
Gainward GeForce 7800GTX Golden Sample
2 Gigs cheap Corsair RAM (not too fast)
Sound Blaster Live! (old reliable one - played X2 for hours).
Not overclocked or anything, sys temp is withing acceptable parameters (checked the NVidia, and Intel docs).
Windows XP SP1, SP2 - problem happens on both of them. Fresh install - no difference, different Intel chipset drivers -no diff, sound on/off no diff, in fact if I turn the sound off the save game won't load at all.
Install is clean, all non essencial services are turned off. Nothing is running except Satek drivers, MS Intellipoint and Intellitype, but I was able to play with those for hours.
I can send the saves, or you can tell me how to get debug info - I can analyse the difference myself (hell, that's what I'm doing everyday). Also if there is any way to check the validity of save files (if there's any) I would like to know that as well. That's because some of the older saves are loading and running allright
Anyway please consider my offer to help.
I also think a lot of people from russian community would like to help in getting bugs fixed.