Hi !
Unfortunately this issue is very tricky and is known for its "unexpected" behavior.
Here are few things that I would ask you to test in order to investigate your case more and maybe even fix it:
1. Previous week i think NVIDIA released new drivers which fixed lots of instability, please check out this link, select your NVIDIA 4080 super card and install new drivers
https://www.nvidia.com/en-us/drivers/
-> if this doesnt help...
2. go to your config.xml (documents/egosoft/x4/config.xml) and find and change the resolution entries:
<fullscreen>false</fullscreen>
<borderless>false</borderless>
<res_width>1904</res_width>
<res_height>1041</res_height>
run and test. did it crash?
3. it would be very helpful if you could record a video with following:
a. open Task Manager in Windows
b. find "Settings" in the left bottom corner and checkbox "always on top"
c. start a game and record the game with Task manager on top (so the moment with crash is also captured). Please open "Performance" tab in Task Manager and select your dedicated GPU
d. if the issue is easy to reproduce then do at least 3 captures and attach the videos here
oh and also attach your config.xml with what you experience a crash !