Cell stage was as simple as you can expect, always something that's bigger than you to eat you there, mostly fun and simple.
Creature stage was somewhat fun though repetitive, since I went the kill anything that moves way (partially unsuccessfully there since I found couple epic creatures that resisted my efforts). I played this stage extra long time to get most of the parts. (to maximize the creatures abilities with little to no regard on the looks)
Tribal stage is trivial, I couldn't figure out the point of this so I just killed everyone and moved on to the next one.
Civilization stage might have been more fun have not one of the others (religious) neighbors gone on the offensive which I was forced to counter by annexing my own neighbors just to keep up with his expansion. it ended up in almost total air war since they had only religious units that couldn't do any damage to my air units. absolutely 0 trading with neighbors occurred on my part....I opted not to nuke him though that was possible for a long time.
Space stage, now it gets really annoying....everyone else can muster up fleets of ships and attack dozen planets each with tens of ships at the same time and you got one ship and none of your planets can defend them selfs even with full turrets in colonies and uber turret, not even against pirates.
So expect to do absolutely nothing else but babysit your empire, if you manege to get 5 mins of no alerts time consider your self lucky.
Oh and it's not just attacks you have to attend to, every 10 mins or so one of your or your allies colonies has a ecological disaster that you have to fix or suffer damage to your standing with that empire.
And then we get to the spice trade, only way to make serious credits. again only you can do it, no one else touches it (well except the pirates). so you will find your self going back and forth between your colonies collecting spice from them and every single time you have to zoom in and out which takes forever (even with ctrl+ or ctrl-) and then you have to find a place that pays good money for that particular color spice, or you can save and load since the price is random. oh and don't bother trying to stockpile since your ship can only hold 99 units of each and planets 30 max (except "home worlds" that have more than 3 colonies)
Only thing you can do to ease your play is NOT to be in war, if you want some one elses world, either make sure you can wipe the whole race out quickly or use other means. (like buying a whole planet or raising an epic creature right next to a town then teasing it until it attacks the town

)
Editors were great though I'm not exactly a creative person so they don't appeal to me so much, I always went the maximized potential way or pure simplicity.
I guess this is EA's next milking cow, expect hordes of addons to start appearing any day now. maybe one of them will eventually evolve this zombie simulation to something entertaining.