I have the game via GOG, and hate running GOG Galaxy (unless I need to check for updates to any games), so I always run games directly from their .exe.
In the case of BG3 that also skips using the annoying game launcher, which in turn then launches the .exe anyway.
I dont have any multiplayer needs so the launcher is not needed at all.
And since starting playtesting the early access, I went with Larians recommendation of using the Vulkan exe = BG3.exe
https://i.imgur.com/PAXtYmO.png
Its never given me any problems with an NVidia card over the last few years. I understand that can be a different story with AMD Radeon type graphics cards though. A few people on the Larian forums had issues .. but then again some had issues with the DX11 exe aswell <shrugs>