I found out that on two of my systems:
1 - 5800x, 5700xt, win10
2 - 8770w, 3620qm, gtx780m (yes, modified), win7 & mint 18.3 (old system, haven't touched

...X3:R would crash when rapidly cycling through targets, no matter the OS, graphics settings (key point - didn't try vsync, I always keep it off) or whatever else I tried. I was playing XTM at first and originally blamed it on seeing a centaur mk3 up close but then tried and actively reproduced this on both the Steam version of X3:R (v2.5a) and the Superbox installer version (v2.5, 2007-ish?) (on the 8770w, still has a DVD) and the same thing happened - new game, start cycling targets and bam. Anyways, tons of threads here and elsewhere that describe this particular behaviour.
I decided to try it on my SP3 (i5-4300u) since it is relatively old and has integrated graphics only and...
...nothing.
I then used rivatuner on my desktop to limit the FPS to 60 and tried to reproduce this - again, nothing. Vsync should have a similar effect (and might explain why a lot of people don't have issues).
I've played X3:R for close to 4 hours without a crash on my main PC, locked at 144fps (matching the monitor refresh, not quite optimal for tearing but not noticing any) and... nothing. Bonus point - no coil whine from the GPU running with furmark power consumption in the main menu

Anyways, couldn't find any references to this having been found before, so here it is. From what I've been told (@Alan Phipps), newer X3-engine games have an FPS cap by default - I guess it explains the lack of these random CTDs manifesting. Might be a good idea to implement this for X3:R as well?

Some threads with (I think) the same thing:
viewtopic.php?t=255428
viewtopic.php?t=298103
viewtopic.php?t=325428
viewtopic.php?t=331306
viewtopic.php?t=337665
viewtopic.php?t=355146
...discussed on steam as well.